He aha ka Nitric Oxide?

ʻO ka Nitric oxide kahi kinoea i hana ʻia e nā pūnaewele e pili ana i ka mumū e pili ana me ka hānō maʻi a i ʻole ka eosinophilic.

He aha ka FeNO?

ʻO ka hoʻāʻo Fractional exhaled Nitric Oxide (FeNO) kahi ala e ana ai i ka nui o ka nitric oxide i loko o ka hanu i hoʻokuʻu ʻia. Hiki i kēia hoʻāʻo ke kōkua i ka ʻike ʻana i ka hānō ma ka hōʻike ʻana i ka pae o ka mumū i loko o nā māmā.

Ka Pono Lapaʻau o FeNO

Hiki i ka FeNO ke hāʻawi i kahi mea hoʻohui noninvasive no ka hōʻoia mua ʻana o ka hānō me ka ATS a me NICE e ʻōlelo ana iā ia ma ke ʻano he ʻāpana o kā lākou mau alakaʻi o kēia manawa a me nā algorithm diagnostic.

Nā Pōkole: ATS, ʻAhahui Thoracic ʻAmelika; FeNO, nitric oxide i hoʻokuʻu ʻia i loko o ka ʻōpū; GINA, Global Initiative for Asthma; ICS, corticosteroid inhaled; NICE, National Institute for Health and Care Excellence.

Ho'ākāka nā kulekele ATS i nā pae FeNO kiʻekiʻe, waena, a me haʻahaʻa i nā pākeke ma ke ʻano he >50 ppb, 25 a 50 ppb, a me <25 ppb. ʻOiai i nā keiki, ua wehewehe ʻia nā pae FeNO kiʻekiʻe, waena, a me haʻahaʻa ma ke ʻano he >35 ppb, 20 a 35 ppb, a me <20 ppb (Papa 1). Paipai ka ATS i ka hoʻohana ʻana i ka FeNO e kākoʻo i kahi hōʻailona o ka hānō kahi e pono ai nā hōʻike kūʻokoʻa, ʻoi aku hoʻi i ka hōʻailona o ka mumū eosinophilic. Ho'ākāka ka ATS i nā pae FeNO kiʻekiʻe (>50 ppb i nā pākeke a me >35 ppb i nā keiki), i ka wā e wehewehe ʻia ai i loko o ke ʻano lapaʻau, e hōʻike ana he loaʻa ka mumū eosinophilic me ka pane ʻana o ka corticosteroid i nā maʻi hōʻailona, ​​ʻoiai nā pae haʻahaʻa (<25 ppb i nā pākeke a me <20 ppb i nā keiki) e hana i kēia mea paʻakikī a pono e wehewehe ʻia nā pae waena me ke akahele.

ʻO nā alakaʻi NICE o kēia manawa, e hoʻohana ana i nā pae ʻoki FeNO haʻahaʻa ma mua o ATS (Papa 1), paipai i ka hoʻohana ʻana o FeNO ma ke ʻano he ʻāpana o ka hana diagnostic kahi e noʻonoʻo ʻia ai kahi hōʻailona o ka hānō i nā pākeke a i ʻole kahi i loaʻa ai ka maopopo ʻole o ka diagnostic i nā keiki. Hoʻākāka hou ʻia nā pae FeNO i loko o kahi pōʻaiapili lapaʻau a me nā hoʻāʻo hou aʻe, e like me ka hoʻāʻo hoʻonāukiuki bronchial e kōkua i ka hōʻailona ma ka hōʻike ʻana i ka hyperresponsiveness airway. Hoʻomaopopo nā alakaʻi GINA i ke kuleana o FeNO i ka ʻike ʻana i ka mumū eosinophilic i ka hānō akā ʻaʻole ʻike i kēia manawa i kahi kuleana no FeNO i nā algorithm diagnostic asthma. Ho'ākāka ka Scottish Consensus i nā ʻoki e like me ka hōʻike ʻana o ka steroid me nā waiwai maikaʻi o >40 ppb i nā poʻe maʻi steroid-naive a me >25 ppb no nā poʻe maʻi ma ICS.