huahana

He aha ka Nitric Oxide?

ʻO ka nitric oxide he kinoea i hana ʻia e nā cell i pili i ka ʻāʻī e pili ana i ka hānō maʻi a i ʻole eosinophilic.

He aha ka FeNO?

ʻO ka hoʻāʻo ʻana i ka Nitric Oxide Fractional exhaled (FeNO) he ala e ana i ka nui o ka nitric oxide i loko o ka hanu ʻana.Hiki i kēia ho'āʻo ke kōkua i ka ʻike ʻana i ka hānō ma o ka hōʻike ʻana i ke kiʻekiʻe o ka mumū i loko o ka māmā.

Hoʻohana kino o FeNO

Hiki i ka FeNO ke hāʻawi i kahi hoʻohui noinvasive no ka ʻike mua ʻana o ka hānō me ka ATS a me ka NICE e ʻōlelo nei ma ke ʻano he ʻāpana o kā lākou alakaʻi a me nā algorithm diagnostic.

Nā pōkole: ATS, American Thoracic Society;FeNO, haʻihaʻi i hoʻokuʻu ʻia i ka nitric oxide;GINA, Global Initiative no ka Asthma;ICS, corticosteroid inhaled;NICE, National Institute for Health and Care Excellence.

ʻO nā alakaʻi alakaʻi ATS e wehewehe i nā pae FeNO kiʻekiʻe, waena, a me ka haʻahaʻa FeNO i nā pākeke he> 50 ppb, 25 a 50 ppb, a me <25 ppb, kēlā me kēia.ʻOiai i loko o nā kamaliʻi, ʻike ʻia nā pae kiʻekiʻe, waena, a haʻahaʻa FeNO he> 35 ppb, 20 a 35 ppb, a me <20 ppb (Papa 1).Manaʻo ka ATS i ka hoʻohana ʻana i ka FeNO e kākoʻo i kahi hōʻailona o ka hānō kahi e pono ai nā hōʻike pahuhopu, ʻoi loa i ka ʻike ʻana o ka mumū eosinophilic.Hōʻike ka ATS i nā kiʻekiʻe FeNO kiʻekiʻe (> 50 ppb i nā pākeke a me> 35 ppb i nā keiki), ke unuhi ʻia i loko o ka pōʻaiapili kino, e hōʻike ana aia ka ʻeha eosinophilic me ka pane ʻana o corticosteroid i nā maʻi maʻi maʻi, ʻoiai nā haʻahaʻa haʻahaʻa (<25 ppb i nā pākeke. a me <20 ppb i nā keiki) e hana i kēia mea hiki ʻole a pono e wehewehe ʻia nā pae waena me ka akahele.

ʻO nā alakaʻi NICE o kēia manawa, e hoʻohana ana i nā pae haʻahaʻa FeNO i ʻoki ʻia ma mua o ATS (Papa 1), e paipai i ka hoʻohana ʻana i ka FeNO ma ke ʻano he ʻāpana o ka hana diagnostic kahi e noʻonoʻo ʻia ai kahi hōʻailona o ka hānō i nā pākeke a i ʻole kahi ʻike maopopo ʻole i nā keiki.Ua unuhi hou ʻia nā pae FeNO i loko o ka pōʻaiapili lapaʻau a me ka hoʻāʻo hou ʻana, e like me ka hoʻāʻo hoʻonāukiuki bronchial hiki ke kōkua i ka maʻi ma o ka hōʻike ʻana i ka hyperresponsiveness ea.Hoʻomaopopo nā alakaʻi GINA i ke kuleana o FeNO i ka ʻike ʻana i ka mumū eosinophilic i ka hānō akā ʻaʻole ʻike i kēia manawa i kahi kuleana no FeNO i nā algorithm diagnostic hānō.ʻO ka Scottish Consensus ka weheweheʻana i nāʻokiʻoki e like me ka hoʻolaha steroid me nā waiwai maikaʻi o> 40 ppb i nā maʻi steroid-naive a me> 25 ppb no nā maʻi ma ICS.